Chromatography

Chromatographie

A lot is expected from your products – in terms of your own interpretation of quality and as laid down in statutory regulations. Our chromatographic services offer you the assurance these expectations will always be met.

To analyze chemical and pharmaceutical products, CURRENTA primarily uses chromatographic methods, particularly gas chromatography (GC) and high-performance liquid chromatography (HPLC). This applies to quality assurance analysis, R&D project analysis and environmental issues.

Ion chromatography can be used to identify both the composition of a product and the content of individual components. We offer content determination for all commonplace anions such as F-, Br-, Cl-, NO2-, NO3-, SO42-, PO43- and for oxalate and citrate as dependable standard analysis on our systems using ion-exchange chromatography. We also have extensive experience in preparing samples and applying methods, especially in the pharmaceutical sector. Even for exotic components, a solution can often be found. We work closely with you and help you develop and validate methods.

Moreover, ion exclusion chromatography also gives us a method for determining anions from organic acids that exhibit poor dissociation, such as fumarate, maleate and even the special case of borate, which we can identify even in trace quantities.

Gel permeation chromatography (GPC, SEC) is used for analyzing polymers and offers access to the distribution of molecular mass or residual monomer content. Special tasks for active ingredient analysis are performed using instrumental thin-layer chromatography (DC, AMD-DC, TLC), which enables screening with high throughput.

Combining chromatography with mass spectrometry (GC-MS, GC-MS/MS, HPLC-MS, HPLC-MS/MS) offers a solution for complex analytical tasks that push the limits, such as trace analytics. In addition to combinations with single-stage mass detectors, CURRENTA Analytics also employs tandem devices and high-resolution mass spectrometers, thus offering a full range of high-resolution GC-MS and LC-MS services.

CURRENTA Analytics can perform chromatographic measurements, including the combinations GC-MS and LC-MS, under GMP and GLP conditions. As a result, a full range of chromatographic methods is available for pharmaceutical analyses, e.g. raw material inspections, method validations and stability studies.

One of our major specialties is the development and validation of methods. Thanks to their expertise and product knowledge, our experienced analysts can grasp the intricacies of your issue. This can lead to interesting approaches that you may not have considered from the outset. We work with you to coordinate the relevant methods. Make the most of our expertise, methods and techniques, taking advantage of as much flexibility and efficiency as your tasks require.

Techniques
  • Gas chromatography (GC)
  • Headspace and headspace-trap-GC-MS
  • Thermal desorption GC-MS
  • Thermal extraction
  • GC detection: FID, ECD, MS, MS/MS, NPD, TEA
  • Liquid chromatography (HPLC)
  • HPLC detection: UV, DAD, RI, MS
  • Gel permeation chromatography (GPC, SEC)
  • Thin-layer chromatography (DC, TLC, AMD-DC)
  • GC-MS, HR-GC/MS
  • LC-MS, HR-LC/MS
  • GC-MS/MS
  • LC-MS/MS
  • Ion chromatography
Application examples
  • Dioxins, Furans
  • Nitrosamines
  • Aromatic halogens, PCBs
  • Aldehydes, isocyanates
  • Perfluorinated surfactants
  • Residual monomers
  • Residual solvents
  • GMP analytics
  • HPLC and GC for GLP studies
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